With the January 2018 implementation of USP <232>/<233> testing criteria for the measurement of elemental impurities in finished drug products, manufacturers must change from traditional wet chemistry methods to recommended instrumental techniques such as inductively couple plasma atomic emission spectrometry (ICP-AES) or inductively coupled plasma mass spectrometry (ICP-MS).

Teledyne CETAC offers a variety of sampling handing and sample introduction accessories for ICP-AES and ICP-MS enabling improved analysis of drug products.

     Application Notes

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    PST2020WCPS_Ariz_U5000AT_USP232_ICPAES.pdfPoster: Measurement of Elemental Impurities in a Higher Daily Dose Drug Product by USP <232>/<233> Using Ultrasonic Nebulization with ICP-AES DetectionU5000AT03/16/2020
    TN-XPRESS-008.pdfRapid‐Throughput USP‐232/233 by Inductively Coupled Plasma Mass SpectroscopyASXPRESS PLUS04/20/2016
    PST2015_WCP_U5000AT_USP232.pdfPoster: Use of Ultrasonic Nebulization with ICP-AES for Enhanced Detection of Regulated Elements in Pharmaceuticals per USP <232>/<233>U5000AT04/20/2016
    AP-U5000-003.pdfMeasurement of Trace Elemental Impurities in Aspirin Using Ultrasonic Nebulization with ICP-OES Detection Following USP <232>/<233> GuidelinesU5000AT08/29/2019
    AP-SimPrep-005.pdfAutomating Sample Preparation to meet USP <232>/<233> GuidelinesSimPrep11/23/2020