​​​​​​​​​The HGX-200 Hydride Generation / Cold Vapor System is a specialized sample introduction accessory for the generation of volatile hydride species or the reduction of mercury to Hg0 (cold vapor) prior to introduction to an ICP-AES or ICP-MS instrument. Hydride forming elements include As, Bi, Ge, Pb, Sb, Se, Sn, and Te.  

​​​​Lower Detection Limits:  Up to 10x or more improvement in instruments detection limits (IDLs) for As, Se, Sb, or Hg with ICP-AES or ICP-MS.

Selective Hydride Generation / Cold Vapor Chemistry: Sample solutions are mixed with a sodium borohydride (NaBH4) solution for hydride generation separately with and Sn(II)/HCl for generation of Hg0. The chemical conversion of the analyte elements offers advantages for measurement with ICP-AES or ICP-MS: nearly 100% analyte transport efficiency with no water loading of the ICP plasma can provide signal enhancements up to 100x. This feature is an important benefit for more difficult elements such as arsenic (As) and selenium (Se).  In addition, the hydride generation and cold vapor reaction provides separation of selected elements from the sample matrix and any potential matrix induced interferences.  Examples include the argon chloride (ArCl+) interferences on 75As+ and 77Se+ and tungsten oxides (WO+) on various Hg isotopes.

​Specialized Gas Liquid Separator:  A specialized u-shaped gas-liquid separator (GLS) includes a frosted glass post, providing a high surface area for liquid film evaporation and release of hydrides and Hg (0).

Inert Membrane Filter:  The GLS also features an a porous fluoropolymer​ membrane filter and a droplet separator to achieve complete gas/liquid separation and reduce background noise.

Dual Gas Flow Inlets:  Dual Ar gas inlets, including an on-board analog flow meter, allow tuning for highest analyte signal and lowest background.​​  A separate gas flow through the GLS (before the inert membrane) allows a lower argon flow, minimizing noise-generating turbulence; additional argon gas is then added after the membrane to complete the needed sample vapor flow to the ICP.

Small Footprint:  The small footprint of the HGX-200 allows convenient placement on a benchtop or the sample rack tray of the CETAC ASX-520/560 Autosamplers.

Easy Setup:  Liquid flow lines (sample, make-up acid, reagents) are color-coded for easy setup; mixing tees are included prior to sample/reagent introduction to the GLS.  The host ICP-AES or ICP-MS peristaltic pump can be used for introduction of samples and reagents. Dedicated reagent bottles and solution mixing blocks are also provided.

 Literature References

Publications showing our products in use. Click column headers to filter and sort. Links to third party sites.
  
AuthorsFilter
  
  
Application
  
A First Look at Dissolved Ge Isotopes in Marine Sediments
Baronas et al.
Frontiers in Earth Science2019Soil; Water
An Optimized Protocal for High Precision Measurement of Hg Isotopic Compositions in samples with Low Concentrations of Hg Using MC-ICP-MS
Geng et al.
J. Anal. At. Spectrom.2018Environmental
A method for Se isotope analysis of low ng-level geological samples via double spike and hydride generation MC-ICP-MS
Kurzawa et al.
Chemical Geology2017Geological
High Precision Determination of Mercury Isotope Ratios Using Online Mercury Vapor Generation System Coupled with Multicollector Inductively Coupled Plasma-Mass Spectrometer
YIN et al.
Chinese Journal of Analytical Chemistry2010Environmental
Isotopic Variability of Mercury in Ore, Mine-Waste Calcine, and Leachates of Mine-Waste Calcine from Areas Mined for Mercury
Stetson et al.
Environmental Science & Technology2009Mining
Sources and exposure of the New Hampshire population to arsenic in public and private drinking water supplies
Peters et al.
Chemical Geology2006Environmental; Water
Impacts of zooplankton composition and algal enrichment and on the accumulation of mercury in an experimental freshwater food web
Pickhardt et al.
Science of the Total Environment2005
Mercury isotope fractionation in fossil hydrothermal systems
Smith et al.
Geology2005Geological
The source and transport of arsenic in a bedrock aquifer
Peters and Blum
Applied Geochemistry2003
Urinary arsenic species in relation to drinking water and toenail arsenic concentrations and genetic polymorphisms in GSTM1 in New Hampshire
Karagas et al.
Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives2002
Algal blooms reduce the uptake of toxic methylmercury in freshwater food webs
Pickhardt et al.
PNAS Biological Sciences: Ecology2002
Markers of low level arsenic exposure for evaluating human cancer risks in a US population
Karagas et al.
Inter. J. Occupational Medicine and Env. Exposure2001
Mercury abundances and isotopic composition in the Murchison (CM) and Allende (CV) carbonaceous chondrites
Lauretta et al.
Geochimica et Cosmochimica Acta2001
Measurement of low levels of arsenic exposure: a comparison of water and toenail concentrations
Karagas et al.
American Journal of Epidemiology2000
Accumulation of heavy metals in food web components across a gradient of lakes
Chen et al.
Limnology and Oceanography2000Environmental; Water
Trace Analyses of Arsenic in Drinking Water by Inductively Coupled Plasma Mass Spectrometry:  High Resolution versus Hydride Generation
Klaue and Blum
Analytical Chemistry1999Water

 Application Notes

  
  
TN_HGX000.pdfEnhanced Detection of Mercury Using the CETAC HGX-200 Cold Vapor / Hydride Generator with Quadrupole ICP-MS Detection
TN_HGX001.pdfImproved Detection of Arsenic, Antimony and Selenium Using the CETAC HGX-200 Hydride Generator with ICP-AES
TN_HGX002.pdfEnhanced Detection of Arsenic and Selenium Using the CETAC HGX-200 Hydride Generator with Quadrupole ICP-MS Detection

 ‭(Hidden)‬ Application Areas

  • ​​Water
  • Environmental Research
  • Geology

 Contact Us

​​Contact us using an​y of the methods below for more information on this or other Teledyne CETAC products.

Email: cetacsales@teledyne.com

Toll Free: 1-800-369-2822

International: +1 402-733-2829​​

 Downloads

 Specs

​​
Specificatio​n Title Specification Details
Gas Flow Meter 1 L/min Argon, up to 200 psi pressure
Reagent Bottles​​ Acid, NaBH4, HCl/Sn(II), 1 Liter each​
Dimensions
     Width      30.5 cm (12 in.)
     ​Height      ​43.8 cm (17.25 in)
     ​Depth      ​21.9 cm (8.75 in)
​Weight ​3.4 kg (7.5 lbs)
Warranty 12 month limited

​​​

 ‭(Hidden)‬ Lit Ref

  1. ​Trace analysis of arsenic in drinking water by inductively coupled plasma mass spectrometry: high resolution versus hydride generation. B. Klaue, & J.D. Blum, Analytical Chem., 71, pp 1408-1414, 1999.
  2. Accumulation of heavy metals in food web components across a gradient of lakes. C.Y Chen, R.S. Stemberger, B. Klaue, J.D. Blum, P. Pickhardt, & C.L. Folt. Limnology and Oceanography45, pp 1525-1536, 2000.
  3. Sources and Exposure of the New Hampshire Population to Arsenic in Public and Private Drinking Water Supplies. S.C. Peters, J.D. Blum, M. Karagas, C.P. Chamberlain, & D.J. Sjostrom, Chemical Geology, 2005.
  4. Isotopic Variability of Mercury in Ore, Mine-Waste Calcine, and Leachates of Mine-Waste Calcine from Areas Mined for Mercury, S.J. Stetson, J.E. Gray, R.B. Wanty, D.L. Macalady, Environ.Sci. Technol., 43 (19) 7331-7336, 2009.
  5. Mercury Isotope Fractionation in Fossil Hydrothermal Systems, C.N. Smith, B. Klaue, S.E. Kesler & J.D. Blum, Geology, 33(10) 825-828, 2005.
  6. High Precision Determination of Mercury Isotope Ratios Using Online Mercury Vapor Generation System Coupled with Multicollector Inductively Coupled Plasma Mass Spectrometer, R. Yin, X. Feng, S. Wen-Feng, D. Foucher, Chin. J. Anal. Chem., 38(7) 2010.
  7. A Method for Se Isotope Analysis of Low ng-level Geological Samples via Double Spike and Hydride Generation MC-ICP-MS, T. Kurzawa, S. König, J. Labidi, A. Yierpan, R. Schoenberg, Chem. Geol. 466, 219-228, 2017.
  8. A First Look at Dissolved Ge Isotopes in Marine Sediments, J.J. Baronas, D.E. Hammond, O.J. Rouxel, D.R. Monteverde, Front. Earth Sci., June 2019.​